Department of Medicine and Buccofacial Surgery, Faculty of Dentistry, Complutense University of Madrid, Spain.
Med Oral Patol Oral Cir Bucal. 2010 Nov 1;15(6):e839-45.
Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. Eventually, PVL tends to become multifocal with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions may occur both in smokers and non-smokers. Nevertheless, at present, the aetiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria. Therefore, the aim of this study is to propose a set of diagnostic criteria to allow for the early and objective identification of PVL cases, and thereby conduct an adequate management. The proposal includes five major criteria and four minor criteria, as well as specific combinations among them in order to establish a correct and objective diagnosis of proliferative verrucous leukoplakia.
增殖性疣状白斑（PVL）是一种罕见的口腔白斑病，于 1985 年由 Hansen 等人首次描述。此后，各种已发表的病例系列报告表明，PVL 具有侵袭性的生物学行为，因为其高复发率和高恶性转化率（通常高于 70%）。PVL 是一种长期进行性疾病，在诊断时更常见于女性和 60 岁以上的老年患者。最终，PVL 往往会变得多灶性，病变逐渐恶化，使其越来越难以控制。吸烟似乎对 PVL 的出现或进展没有明显影响。这些病变可能发生在吸烟者和不吸烟者中。然而，目前，PVL 的病因以及其管理和诊断仍不清楚，仍然是回顾性的、晚期的和定义不明确的，缺乏共识标准。因此，本研究旨在提出一组诊断标准，以便能够早期和客观地识别 PVL 病例，并进行适当的管理。该建议包括五个主要标准和四个次要标准，以及它们之间的特定组合，以便对增殖性疣状白斑进行正确和客观的诊断。
