Faculty of Odontology, University Complutense, Madrid, Spain.
Med Oral Patol Oral Cir Bucal. 2010 Sep 1;15(5):e732-8. doi: 10.4317/medoral.15.e732.
To assess the effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in preventing the oral complications associated to radiation therapy in head-and-neck cancer patients.
This was a parallel, double blind, prospective, randomized clinical trial. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Different outcome variables were evaluated: mucositis, plaque and gingival indices, stimulated saliva and salivary pH.
70 patients were screened and 36 were included. The presence and the degree of mucositis significantly increased in both groups and no significant differences were detected between groups, although the median increase in the placebo group (1.81) at 2 weeks was higher than in the test group (1.20).
Within the limitations of the small sample size, this study suggests that the use of the tested mouth-rinse may lead to some improvements in clinical parameters in patients irradiated for head-and-neck cancer.
评估一种含有洗必泰和十六烷基吡啶氯的新型、非酒精基抗菌漱口液在预防头颈部癌症放疗患者口腔并发症方面的效果。
这是一项平行、双盲、前瞻性、随机临床试验。癌症患者被随机分配到两种治疗方法（实验组漱口液或安慰剂组）之一。共安排了三次就诊（基线、第 14 天和第 28 天）。评估了不同的结果变量：粘膜炎、菌斑和牙龈指数、刺激性唾液和唾液 pH 值。
共筛选了 70 名患者，其中 36 名患者入组。两组的粘膜炎发生率和严重程度均显著增加，但组间无显著差异，尽管安慰剂组在第 2 周时的中位数增加（1.81）高于实验组（1.20）。
在小样本量的限制下，本研究表明，在头颈部癌症放疗患者中使用测试漱口液可能会在临床参数方面带来一些改善。
