Faculty of Odontology, University Complutense, Madrid, Spain.
Med Oral Patol Oral Cir Bucal. 2011 Nov 1;16(7):e1036-42.
To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer.
This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiated as part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue, mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of the Mann-Whitney, Wilcoxon and chi-square tests.
70 patients were screened and 36 were included. The detection of Candida species in mucosa and tongue samples showed significant reductions in the test group. Total bacterial counts decreased in both groups from baseline to the 2-week visit, while minor changes occurred between 2 and 4 weeks (effects on P. gingivalis, P. intermedia, C. rectus, E. corrodens).
Within the limitations of the small sample size, this study suggests that the use of the tested mouth-rinse may lead to improvements in microbiological parameters in patients irradiated for head-and-neck cancer.
评估一种含洗必泰及西吡氯铵的新型、非酒精性口腔抗菌剂对头颈部癌症放疗患者的口腔微生物学影响。
这是一项平行、双盲、前瞻性、随机临床试验，纳入年龄 18-75 岁、正在接受头颈部癌症放疗且至少有 10 颗牙齿、愿意签署知情同意书的患者。癌症患者被随机分配至实验组（试验性漱口液）或对照组（安慰剂）。共进行 3 次访视（基线、14 天和 28 天）。采用培养法评估舌、口腔黏膜和龈下样本的微生物学发现。采用曼-惠特尼、威尔科克森和卡方检验评估微生物学变量。
70 名患者接受筛查，36 名患者入选。实验组口腔黏膜和舌样本中真菌（白色念珠菌）的检出率显著降低。两组患者的总细菌计数均从基线至 2 周访视时下降，而在 2-4 周之间发生轻微变化（对牙龈卟啉单胞菌、中间普氏菌、直肠弯曲菌、侵蚀艾肯菌的影响）。
在样本量较小的限制条件下，本研究提示使用受试漱口液可能对头颈部癌症放疗患者的口腔微生物学参数产生有益影响。
