Department of Oral Medicine and Dental Research Center, Dental School, Tehran university of Medical Sciences, Tehran, Iran.
Med Oral Patol Oral Cir Bucal. 2010 Jul 1;15(4):e557-61. doi: 10.4317/medoral.15.e557.
The aim of this study was to determine the possible association of oxidant/antioxidant status and recurrent aphthous stomatitis (RAS).
The study consisted of thirty-one patients with RAS and thirty-two healthy controls from whom saliva and blood samples were collected. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) were measured in erythrocytes and total antioxidant status (TAS) was measured in plasma and saliva.
Erythrocyte SOD activity was significantly lower in RAS patients in comparison to healthy controls (P=0.012). No significant differences were found in erythrocyte GSHPx, CAT activities, and salivary and plasma TAS between RAS patients and control subjects (p>0.1).
Changes in SOD activity may be important in the inflammatory reactions observed in RAS, but other tested defense systems such as CAT and GSHPx do not seem to play a primary role in the aetiopathogenesis of RAS. Moreover, the antioxidant system in saliva and plasma is not as affected as in erythrocytes in RAS patients, and therefore it may not be considered an appropriate indicator of the body's total antioxidant status.
本研究旨在探讨氧化应激状态与复发性阿弗他溃疡（RAS）之间的可能关联。
该研究纳入了 31 例 RAS 患者和 32 名健康对照者，采集了唾液和血液样本。测量了红细胞中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSHPx）和过氧化氢酶（CAT）的活性，以及血浆和唾液中的总抗氧化状态（TAS）。
与健康对照组相比，RAS 患者的红细胞 SOD 活性显著降低（P=0.012）。RAS 患者与对照组之间的红细胞 GSHPx、CAT 活性以及唾液和血浆 TAS 无显著差异（p>0.1）。
SOD 活性的变化可能在 RAS 观察到的炎症反应中很重要，但其他测试的防御系统，如 CAT 和 GSHPx，似乎在 RAS 的发病机制中不起主要作用。此外，RAS 患者的唾液和血浆中的抗氧化系统不像红细胞那样受到影响，因此不能将其视为全身总抗氧化状态的合适指标。
