Najafi Shamsolmolouk, Mohammadzadeh Mahsa, Zahedi Amirabbas, Heidari Mansour, Rezaei Nima
Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
International Campus, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Avicenna J Med Biotechnol. 2018 Jan-Mar;10(1):56-60.
Recurrent Aphthous Stomatitis (RAS) is one of the most common diseases of the oral cavity all over the world (5-66%). RAS has a multifactorial etiology, while psychological factors such as stress and anger play a role in its manifestation. The serotonergic mechanisms particularly the serotonin-transporter gene () may affect the risk of psychological alterations and stress response. The aim of the present study was to evaluate the polymorphism of the promoter region of () in the patients with RAS, compared to that in the control subjects.
In this case-control study, 100 patients with RAS and 100 healthy subjects were enrolled. PCR was performed on DNA of the samples, using a pair of primers capable of distinguishing S/L alleles and replicating .
No statistically significant difference existed between LL and LS genotype frequencies in the case and control groups. However, SS genotype frequency was significantly higher in the case group, as compared to the control group (p=0.001).
The conclusion of the present study demonstrated that S allele could approximately double the risk of RAS.
复发性阿弗他口炎（RAS）是全球最常见的口腔疾病之一（发病率为5 - 66%）。RAS病因多因素，而压力和愤怒等心理因素在其发病中起作用。血清素能机制尤其是血清素转运体基因（）可能影响心理改变和应激反应风险。本研究目的是评估RAS患者与对照者相比的（）启动子区域多态性。
在本病例对照研究中，纳入100例RAS患者和100例健康受试者。使用一对能够区分S/L等位基因并扩增的引物对样本DNA进行聚合酶链反应（PCR）。
病例组和对照组的LL和LS基因型频率无统计学显著差异。然而，与对照组相比，病例组的SS基因型频率显著更高（p = 0.001）。
本研究结论表明S等位基因可使RAS风险增加约一倍。
