Myc 调控的 miR-9 导致更多转移。

Myc-modulated miR-9 makes more metastases.

机构信息

Centre for Cancer Biology, SA Pathology, Adelaide, Australia.

出版信息

Nat Cell Biol. 2010 Mar;12(3):209-11. doi: 10.1038/ncb0310-209. Epub 2010 Feb 21.

PMID:20173743

Abstract

The microRNA miR-9 is induced by Myc in breast cancer cells where it targets the major epithelial adherens junction protein, E-cadherin. This primes the cancer cells for epithelial-mesenchymal transition (EMT) and also stimulates angiogenesis in tumours.

摘要

在乳腺癌细胞中，miR-9 可被 Myc 诱导，其靶标是主要的上皮细胞黏附连接蛋白 E-钙黏蛋白。这使得癌细胞易于发生上皮-间充质转化（EMT），并刺激肿瘤中的血管生成。