术后即刻膀胱内灌注丝裂霉素C后发生膀胱穿孔。
Bladder perforation after immediate postoperative intravesical instillation of mitomycin C.
作者信息
Lim Darwin, Izawa Jonathan I, Middlebrook Paul, Chin Joseph L
机构信息
Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON;
出版信息
Can Urol Assoc J. 2010 Feb;4(1):E1-3. doi: 10.5489/cuaj.781.
Abstract
Intravesical chemotherapy after transurethral resection of a bladder tumour (TURBT) has been observed to significantly decrease recurrence rates compared to TURBT alone. Though immediate postoperative intravesical treatment with chemotherapeutic agents after transurethral resection for superficial bladder carcinoma is generally considered a safe and effective adjunctive therapy in decreasing recurrence rates, its instillation is not always completely innocuous. Lately, a more serious complication of bladder perforation associated with immediate instillation of intravesical mitomycin C (MMC) after TURBT was reported. We report our own experience of a male patient with bladder perforation after an early instillation of a single dose of MMC. In this case, systemic toxicity occurred which required intensive care after surgical repair.
摘要
经尿道膀胱肿瘤电切术（TURBT）后膀胱内化疗与单纯TURBT相比，已观察到可显著降低复发率。虽然经尿道浅表性膀胱癌电切术后立即膀胱内使用化疗药物治疗通常被认为是降低复发率的一种安全有效的辅助治疗方法，但其灌注并非总是完全无害。最近，有报道称TURBT后立即灌注膀胱内丝裂霉素C（MMC）会出现更严重的膀胱穿孔并发症。我们报告了1例男性患者在早期单次灌注MMC后发生膀胱穿孔的自身经验。在该病例中，出现了全身毒性反应，手术修复后需要重症监护。
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