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经尿道膀胱肿瘤电切术后早期膀胱内灌注丝裂霉素C的一种罕见并发症。

A rare complication of intravesical early instillation of mitomycin C after TURBT.

作者信息

Hatem Humam, Leifeld Jörg

机构信息

Department of Urology in Borromäus Hospital Leer, Germany.

出版信息

Urol Case Rep. 2019 Jun 26;26:100955. doi: 10.1016/j.eucr.2019.100955. eCollection 2019 Sep.

DOI:10.1016/j.eucr.2019.100955
PMID:31334032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6616476/
Abstract

The early intravesical Instillation of mitomycin C (MMC) is accepted as safe adjuvant therapy after TURBT by non-muscle- invasive bladder cancer if there is no perforation. In our case we report a female patient undergoing resection of papillary recurrent tumor on the anterior bladder wall. In the early postoperative period had the patient no complaints regarding to Instillation of MMC. The clinical manifestation of the necrosis of the anterior bladder wall appeared after one week requiring a long extended unsuccessful conservative therapy in order to save the bladder. Finally we performed a radical cystectomy. This complication is reported by some authors in literature.

摘要

对于非肌层浸润性膀胱癌,若未发生穿孔,术后早期膀胱内灌注丝裂霉素C(MMC)被认为是经尿道膀胱肿瘤电切术(TURBT)后的安全辅助治疗方法。在我们的病例报告中,有一位女性患者接受了膀胱前壁乳头状复发肿瘤切除术。术后早期,患者对MMC灌注无任何不适主诉。一周后出现膀胱前壁坏死的临床表现,为挽救膀胱进行了长时间的保守治疗但未成功。最终我们实施了根治性膀胱切除术。文献中已有一些作者报道过这种并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b03f/6616476/e4d752002e12/egi10LPK00GW84.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b03f/6616476/e4d752002e12/egi10LPK00GW84.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b03f/6616476/e4d752002e12/egi10LPK00GW84.jpg

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本文引用的文献

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Can J Urol. 2018 Dec;25(6):9579-9584.
2
Complications associated with single-dose, perioperative mitomycin-C for patients undergoing bladder tumor resection.单剂量围手术期丝裂霉素-C用于膀胱肿瘤切除术患者的相关并发症。
Urol Oncol. 2014 Jan;32(1):40.e1-8. doi: 10.1016/j.urolonc.2013.04.006. Epub 2013 Jun 17.
3
Intravesical instillation of mitomycin C: a cause of delayed bladder perforation?
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Case Rep Urol. 2012;2012:576519. doi: 10.1155/2012/576519. Epub 2012 Dec 23.
4
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