肌萎缩侧索硬化症患者钩束束的弥散张量束特定分析。
Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis.
机构信息
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyō, Tokyo, Japan.
出版信息
Neuroradiology. 2010 Aug;52(8):729-33. doi: 10.1007/s00234-010-0653-1. Epub 2010 Feb 20.
INTRODUCTION
The uncinate fasciculus (UF) consists of core fibers connecting the frontal and temporal lobes and is considered to be related to cognitive/behavioral function. Using diffusion tensor tractography, we quantitatively evaluated changes in fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) of the UF by tract-specific analysis to evaluate the damage of the UF in patients with amyotrophic lateral sclerosis (ALS).
METHODS
We obtained diffusion tensor images of 15 patients with ALS and 9 age-matched volunteers.
RESULTS
Patients with ALS showed significantly lower mean FA (P = 0.029) compared with controls. No significant difference was seen in mean ADC.
CONCLUSION
The results suggest that damage of the UF in patients with ALS can be quantitatively evaluated with FA.
简介
钩束（UF）由连接额叶和颞叶的核心纤维组成，被认为与认知/行为功能有关。我们通过束特异性分析，使用弥散张量纤维束追踪技术定量评估了肌萎缩侧索硬化（ALS）患者 UF 的分数各向异性（FA）和表观扩散系数（ADC）的变化，以评估 UF 的损伤。
方法
我们获得了 15 名 ALS 患者和 9 名年龄匹配的志愿者的弥散张量图像。
结果
与对照组相比，ALS 患者的平均 FA 值显著降低（P = 0.029）。平均 ADC 未见显著差异。
结论
结果表明，FA 可定量评估 ALS 患者 UF 的损伤。
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