Christidi Foteini, Karavasilis Efstratios, Velonakis Georgios, Ferentinos Panagiotis, Rentzos Michail, Kelekis Nikolaos, Evdokimidis Ioannis, Bede Peter
First Department of Neurology, Aeginition Hospital National and Kapodistrian University of Athens, Athens, Greece.
Second Department of Radiology, General University Hospital "Attikon", National and Kapodistrian University of Athens, Athens, Greece.
Front Neurol. 2018 Jul 3;9:523. doi: 10.3389/fneur.2018.00523. eCollection 2018.
Hippocampal pathology in Amyotrophic Lateral Sclerosis (ALS) remains surprisingly under recognized despite compelling evidence from neuropsychology, neuroimaging and neuropathology studies. Hippocampal dysfunction contributes significantly to the clinical heterogeneity of ALS and requires structure-specific cognitive and neuroimaging tools for accurate evaluation. Recent imaging studies have generated unprecedented insights into the presymptomatic and longitudinal processes affecting this structure and have contributed to the characterisation of both focal and network-level changes. Emerging neuropsychology data suggest that memory deficits in ALS may be independent from executive dysfunction. In the era of precision medicine, where the development of individualized care strategies and patient stratification for clinical trials are key priorities, the comprehensive review of hippocampal dysfunction in ALS is particularly timely.
尽管神经心理学、神经影像学和神经病理学研究提供了有力证据，但肌萎缩侧索硬化症（ALS）中的海马体病理学仍令人惊讶地未得到充分认识。海马体功能障碍在很大程度上导致了ALS的临床异质性，需要针对特定结构的认知和神经影像学工具进行准确评估。最近的影像学研究对影响该结构的症状前和纵向过程产生了前所未有的见解，并有助于表征局灶性和网络水平的变化。新出现的神经心理学数据表明，ALS中的记忆缺陷可能独立于执行功能障碍。在精准医学时代，制定个性化护理策略和为临床试验进行患者分层是关键优先事项，对ALS中海马体功能障碍进行全面综述尤为及时。
