Department of Biochemistry and Molecular Biology, Xinxiang Medical University, Jinsui Road, Xinxiang, Henan, 453003, People's Republic of China.
Mol Biol Rep. 2010 Oct;37(7):3553-60. doi: 10.1007/s11033-010-0003-8. Epub 2010 Feb 22.
Genomic DNA encompasses several levels of organization, the nuclear matrix mediates the formation of DNA loop domains that are anchored to matrix attachment regions (MARs). By means of specific interaction with MAR binding proteins (MARBPs), MAR plays an important regulation role in enhancing transgene expression, decreasing expression variation among individuals of different transformants and serving as the replication origin. Through these years, some MARBPs have been identified and characterized from humans, plants, animals and algae so far and the list is growing. Most of MARBPs exist in a co-repressor/co-activator complex and involve in chromosome folding, regulation of gene expression, influencing cell development and inducing cell apoptosis. This review covers recent advances that have contributed to our understanding of MARBPs.
基因组 DNA 包含几个层次的组织，核基质介导 DNA 环域的形成，这些环域锚定到基质附着区 (MAR)。通过与 MAR 结合蛋白 (MARBP) 的特异性相互作用，MAR 在增强转基因表达、降低不同转化体个体之间的表达变异性以及作为复制起点方面发挥着重要的调节作用。多年来，已经从人类、植物、动物和藻类中鉴定和表征了一些 MARBPs，而且这个列表还在不断增加。大多数 MARBPs 存在于共抑制因子/共激活因子复合物中，并参与染色体折叠、基因表达调控、影响细胞发育和诱导细胞凋亡。本综述涵盖了有助于我们理解 MARBPs 的最新进展。
