Department of Psychology, University of Nevada, Las Vegas, NV 89154, USA.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2010;17(4):422-38. doi: 10.1080/13825580903469838. Epub 2010 Feb 19.
Previous studies have indicated that aging is associated with declines in recollection whereas familiarity-based recognition is left largely unaffected. The brain changes underlying these recollection declines are yet not well understood. In the current study we examined the role of white matter integrity as measured by white matter hyperintensities (WMH) on age-related changes in recollection and familiarity. Recognition was measured using a remember/know procedure (Experiment 1) and a source-memory process-dissociation procedure (Experiment 2). Robust age related declines in recollection were observed, but there was no evidence that white matter damage was related to the observed memory declines. Although future studies with larger samples will be necessary to fully characterize the role of WMH in normal age-related declines in different types of memory, the results suggest that declines in recollection are not strongly related to the brain changes indexed by WMHs.
先前的研究表明，衰老与回忆能力下降有关，而基于熟悉度的识别则基本不受影响。然而，这些回忆能力下降背后的大脑变化尚不清楚。在本研究中，我们考察了脑白质完整性（以脑白质高信号为指标）在回忆和熟悉度随年龄变化中的作用。使用记忆/知道程序（实验 1）和来源记忆过程分离程序（实验 2）来测量识别。观察到与年龄相关的回忆能力明显下降，但没有证据表明脑白质损伤与观察到的记忆下降有关。虽然未来需要更大的样本量来充分描述脑白质高信号在不同类型记忆的正常年龄相关下降中的作用，但结果表明，回忆能力的下降与脑白质高信号所反映的大脑变化没有很强的关系。
