Psychology Department, University of Nevada, Las Vegas, NV 89154, United States.
Neuropsychologia. 2011 Aug;49(10):2817-24. doi: 10.1016/j.neuropsychologia.2011.06.003. Epub 2011 Jun 13.
This study examined the relationship between white matter hyperintensities (WMH) and executive functioning on episodic memory in a group of older adults who were cognitively normal or diagnosed with MCI or dementia. Volumetric magnetic resonance imaging (MRI) measures of total brain volume, white matter hyperintensity volume, and hippocampal volume along with age, education, and gender were evaluated as predictors of episodic memory. WMH were found to influence both episodic memory and executive functioning independently of other variables. The influence WMH on episodic memory was mediated by executive functioning and was completely eliminated when the interaction between executive functioning and hippocampal volume was entered in the regression model. The results indicate that executive functioning mediates the effects of WMH on episodic memory but that executive functioning and hippocampal volume can also interact such that executive functioning can exacerbate or ameliorate the influence of hippocampal volume on episodic memory.
本研究考察了认知正常或被诊断为 MCI 或痴呆的老年人群中，脑白质高信号（WMH）与情景记忆的执行功能之间的关系。对全脑体积、脑白质高信号体积和海马体体积的容积磁共振成像（MRI）测量值以及年龄、教育程度和性别进行了评估，作为情景记忆的预测指标。结果发现，WMH 独立于其他变量影响情景记忆和执行功能。当将执行功能与海马体体积之间的相互作用纳入回归模型时，WMH 对情景记忆的影响是通过执行功能介导的，并且完全消除了。结果表明，执行功能介导了 WMH 对情景记忆的影响，但执行功能和海马体体积也可以相互作用，从而使执行功能可以加剧或减轻海马体体积对情景记忆的影响。
