Department of Psychology, Columbia University, Room 406, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA.
Dev Psychobiol. 2010 May;52(4):299-311. doi: 10.1002/dev.20436.
The critical role of social interactions in driving phenotypic variation has long been inferred from the association between early social deprivation and adverse neurodevelopmental outcomes. Recent evidence has implicated molecular pathways involved in the regulation of gene expression as one possible route through which these long-term outcomes are achieved. These epigenetic effects, though not exclusive to social experiences, may be a mechanism through which the quality of the social environment becomes embedded at a biological level. Moreover, there is increasing evidence for the transgenerational impact of these early experiences mediated through changes in social and reproductive behavior exhibited in adulthood. In this review, recent studies which highlight the epigenetic effects of parent-offspring, peer and adult social interactions both with and across generations will be discussed and the implications of this research for understanding the developmental origins of individual differences in brain and behavior will be explored.
社会互动在驱动表型变异方面的关键作用，长期以来一直可以从早期社会剥夺与不良神经发育结果之间的关联中推断出来。最近的证据表明，参与基因表达调控的分子途径可能是实现这些长期结果的一种途径。这些表观遗传效应虽然不是社会经验所独有的，但可能是社会环境质量在生物学水平上嵌入的一种机制。此外，越来越多的证据表明，这些早期经验通过成年期表现出的社会和生殖行为的变化在代际间产生影响。在这篇综述中，将讨论最近的研究，这些研究强调了亲子、同伴和成人社会互动的表观遗传效应，包括代内和代际的影响，并探讨了这一研究对理解大脑和行为个体差异的发育起源的意义。
