Elia J, Borcherding B G, Rapoport J L, Keysor C S
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
Psychiatry Res. 1991 Feb;36(2):141-55. doi: 10.1016/0165-1781(91)90126-a.
The response to stimulant drugs of 48 boys with attention deficit/hyperactivity disorder was measured following dextroamphetamine, methylphenidate, and placebo in a double-blind crossover study. To distinguish lack of behavioral improvement from adverse drug effects, a day hospital setting and a wide dose range were used. Both drugs were highly and equally efficacious for the group as a whole, and frequently one drug or the other was superior for an individual child, or adverse effects occurred only on one of the stimulants. Only one of the 48 boys (2%) was discharged without the recommendation for continued stimulant drug treatment. "Nonresponse" appears to be extremely rare when both stimulants and a wide range of doses are given.
在一项双盲交叉研究中，对48名患有注意力缺陷/多动障碍的男孩分别给予右旋苯丙胺、哌甲酯和安慰剂后，测定了他们对兴奋剂药物的反应。为了区分行为改善不足与药物不良反应，研究采用了日间医院环境和较宽的剂量范围。两种药物对整个群体都具有高度且同等的疗效，并且对于个体儿童而言，常常一种药物比另一种更有效，或者不良反应仅在其中一种兴奋剂上出现。48名男孩中只有1名（2%）在没有继续使用兴奋剂药物治疗建议的情况下出院。当同时给予两种兴奋剂和较宽的剂量范围时，“无反应”似乎极为罕见。
