Adewoye E O, Taiwo V O, Olayioye F A
Department of Physiology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Afr J Med Med Sci. 2009 Jun;38(2):109-17.
Anti-hyperglycemic and anti-oxidant properties of methanolic (MEMS) and aqueous (AEMS) extracts of Musa sapientum roots were investigated in alloxan-induced diabetic rats. Thirty adult male Wistar albino rats divided into five groups of 6 rats each were used: group 1--non-diabetic untreated (controls), group 2--diabetic untreated, and groups 3, 4 and 5--diabetic rats treated with 250 mg/kg bodyweight MEMS and AEMS, and 500 mg/kg bodyweight glibenclamide (a standard anti-diabetic drug), respectively. There was severe progressive weight loss in the untreated diabetic rats, while the rats in all the treated diabetic groups gained weight. While there was progressive hyperglycaemia in untreated diabetic rats; with blood glucose levels reaching a peak of 335.5 +/- 1.1 mg/dl on day 7 post-induction, compared to 76.8 +/- 0.8 mg/dl on day 0, these values were reduced to 80.7 +/- 0.5, 86.6 +/- 0.6 and 86.8 +/- 0.5 in MEMS, AEMS and glibenclamide-treated diabetic rats 15 days post-treatment. Also there were decreases in serum lipid peroxidation and increases in serum superoxide dismutase activities in MEMS, AEMS and glibenclamide-treated diabetic rats 15 days post-treatment. Lesions observed in the organs of untreated diabetic rats include selective necrosis of pancreatic beta islet cells, hepatocellular degeneration and necrosis, glomerulonephrosis and cardiovascular degeneration. Treatment of diabetic rats with AEMS and glibenclamide caused a total mitigation, while treatment with the MEMS achieved partial but considerable reduction in the severity of the lesions. It is concluded that aqueous and methanolic extracts of Musa sapientum roots possess anti-diabetic activities comparable to glibenclamide.
在四氧嘧啶诱导的糖尿病大鼠中，研究了香蕉根甲醇提取物（MEMS）和水提取物（AEMS）的降血糖和抗氧化特性。选用30只成年雄性Wistar白化大鼠，分为5组，每组6只：第1组为未治疗的非糖尿病大鼠（对照组），第2组为未治疗的糖尿病大鼠，第3、4和5组为分别用250 mg/kg体重的MEMS、AEMS和500 mg/kg体重的格列本脲（一种标准抗糖尿病药物）治疗的糖尿病大鼠。未治疗的糖尿病大鼠体重严重逐渐减轻，而所有治疗组的糖尿病大鼠体重增加。未治疗的糖尿病大鼠血糖逐渐升高，诱导后第7天血糖水平达到峰值335.5±1.1 mg/dl，而诱导前第0天为76.8±0.8 mg/dl，治疗15天后，MEMS、AEMS和格列本脲治疗的糖尿病大鼠血糖分别降至80.7±0.5、86.6±0.6和86.8±0.5 mg/dl。治疗15天后，MEMS、AEMS和格列本脲治疗的糖尿病大鼠血清脂质过氧化也降低，血清超氧化物歧化酶活性增加。未治疗的糖尿病大鼠器官观察到的病变包括胰腺β胰岛细胞选择性坏死、肝细胞变性和坏死、肾小球肾炎和心血管变性。AEMS和格列本脲治疗糖尿病大鼠可使病变完全缓解，而MEMS治疗可使病变严重程度部分但显著降低。得出结论：香蕉根的水提取物和甲醇提取物具有与格列本脲相当的抗糖尿病活性。
