茎提取物对焦虑症实验模型的影响。
Effects stem extract on experimental models of anxiety.
作者信息
Reddy Aditya Jielella, Dubey Ashok Kumar, Handu Shailendra, Sachin Manocha, Mediratta Pramod Kumari, Mushtaq Qazi Ahmed
机构信息
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India.
出版信息
Avicenna J Phytomed. 2017 Nov-Dec;7(6):495-501.
OBJECTIVE
The (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of stem (MSSE) in experimental models in mice.
MATERIAL AND METHODS
Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam.
RESULTS
The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses.
CONCLUSION
The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.
目的
在先前的研究中，（香蕉）植物提取物已显示出抗氧化活性。氧化应激是与焦虑症发病机制相关的重要因素之一。本研究旨在评估香蕉茎水提取物（MSSE）在小鼠实验模型中的抗焦虑活性。
材料与方法
采用高架十字迷宫法和用光感计进行运动监测。将动物分为五个不同的组（每组n = 6）。在实验前，载体组、标准组和实验组分别给予蒸馏水（10 ml/kg）、地西泮（1 mg/kg腹腔注射）和递增剂量的25、50和100 mg/kg的MSSE。标准组接受地西泮。
结果
与对照组相比，MSSE处理组的开臂进入次数和在开臂中花费的时间显著增加，且呈剂量依赖性。与对照组相比，MSSE处理组在闭臂中花费的时间显著减少，且呈剂量依赖性。在所有三个测试剂量下，MSSE还显著降低了运动活性。
结论
本研究结果表明MSSE具有抗焦虑活性，这使其成为治疗焦虑症的潜在天然化合物。
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