Department of Gastroenterology, Benizelion General Hospital, L Knossou, Heraklion, Crete 71409, Greece.
Expert Opin Drug Saf. 2010 Mar;9(2):355-64. doi: 10.1517/14740331003672579.
Opioids play an important role in every aspect of modern anesthetic practice. Remifentanil is an ultra-short-acting opioid featuring a unique pharmacokinetic profile allowing clinical versatility and improved control of its action. In this review, we assess the pharmacology of remifentanil, its clinical uses as well as safety issues on its action on the major organ systems and in particular clinical settings.
A synthesis of evidence from a MEDLINE search for articles from 1993 to 2009 for available up-to-date information on remifentanil and its current applications and safety profile.
A synopsis of the unique pharmacokinetic properties of remifentanil and its action on major organ systems will provide insight on the safe and effective use of the drug in a variety of clinical settings.
Remifentanil is a valuable opioid in the armamentarium of the clinician, providing great clinical flexibility and safety but vigilance is required to avoid pitfalls.
阿片类药物在现代麻醉实践的各个方面都起着重要的作用。瑞芬太尼是一种超短效阿片类药物，具有独特的药代动力学特征，使临床具有多功能性，并能更好地控制其作用。在这篇综述中，我们评估了瑞芬太尼的药理学、其临床用途以及其对主要器官系统作用的安全性问题，特别是在临床环境中的安全性问题。
对从 1993 年到 2009 年的 MEDLINE 搜索文章进行综合，以获取关于瑞芬太尼及其当前应用和安全性概况的最新信息。
对瑞芬太尼独特药代动力学特性及其对主要器官系统作用的概述，将为在各种临床环境中安全有效地使用该药物提供深入了解。
瑞芬太尼是临床医生武器库中的一种有价值的阿片类药物，提供了极大的临床灵活性和安全性，但需要警惕以避免陷阱。
