Women's Health Center, American Hospital, Istanbul, Turkey.
Gynecol Endocrinol. 2010 Jun;26(6):440-4. doi: 10.3109/09513591003632209.
Menopause is associated with accelerated bone loss, a decrease in lean mass, an increase and redistribution of fat mass in the trunk region. Trunk obesity has been considered as a risk factor for endometrial cancer. We aimed to determine if body composition and fat distribution are determinants of femoral neck bone mineral density (BMD) and endometrial thickness in healthy postmenopausal women.
Subjects were 40 healthy postmenopausal women with biopsy proven atrophic endometrium. Anthropometrical variables (total fat mass, trunk and leg fat masses, lean body mass and femoral neck BMD) were measured by dual energy X-ray absorptiometry.
Femoral neck BMD was positively correlated with body mass index, total fat mass, trunk fat mass, leg fat mass and endometrial thickness, and negatively correlated with age, years since menopause and FSH levels. Trunk fat and age remained significant determinants of femoral neck BMD (R(2) = 32.9 %, p < 0.001) and endometrial thickness was significantly associated with femoral neck BMD and oestradiol levels (R(2) = 46.5%, p < 0.0001) on regression analysis.
Truncal adiposity rather than overall adiposity or lean mass are more closely associated with femoral neck BMD and there is no relationship between subcutaneous fat mass and endometrial thickness in postmenopausal women.
绝经后妇女骨量流失加速，瘦体重减少，躯干区域脂肪量增加和分布改变。躯干肥胖被认为是子宫内膜癌的一个危险因素。我们旨在确定体成分和脂肪分布是否是健康绝经后妇女股骨颈骨密度（BMD）和子宫内膜厚度的决定因素。
研究对象为 40 名经活检证实为萎缩性子宫内膜的健康绝经后妇女。通过双能 X 射线吸收法测量人体测量学变量（总脂肪量、躯干和腿部脂肪量、瘦体重和股骨颈 BMD）。
股骨颈 BMD 与体重指数、总脂肪量、躯干脂肪量、腿部脂肪量和子宫内膜厚度呈正相关，与年龄、绝经后年限和 FSH 水平呈负相关。躯干脂肪量和年龄仍然是股骨颈 BMD 的重要决定因素（R²=32.9%，p<0.001），而子宫内膜厚度与股骨颈 BMD 和雌二醇水平显著相关（R²=46.5%，p<0.0001）。
躯干肥胖与股骨颈 BMD 的相关性比总体肥胖或瘦体重更密切，绝经后妇女的皮下脂肪量与子宫内膜厚度之间没有关系。
