Gentil Paulo, Lima Ricardo Moreno, Jacó de Oliveira Ricardo, Pereira Rinaldo Wellerson, Reis Victor Machado
Programa de pós-graduação em Educação Física, Universidade Católica de Brasília, Brasília, Brazil.
J Clin Densitom. 2007 Apr-Jun;10(2):174-8. doi: 10.1016/j.jocd.2007.01.004. Epub 2007 Mar 7.
Aging is associated with several physiological changes that lead to increased disability and mortality. Examples of these changes are deteriorations in bone and muscle tissues, referred, respectively, as osteopenia and sarcopenia. Both have been linked to multiple morbid outcomes in older adults. The main purpose of this study was to determine the association between femoral neck and trochanter bone mineral density (BMD) and lower limb non-bone fat-free mass (MM) in postmenopausal women. One hundred eighty nine postmenopausal women volunteered to participate in the study (mean age 66.92+/-5.23 yr). Subjects were divided into different groups according to lower limb MM, femoral neck, and trochanter BMD measurements using the 2-step cluster analysis. Pearson chi-square was used to analyze the correlation between the BMD and MM distributions. The 2-step cluster analysis leads to the formation of 3 groups according to the levels of lower limb MM (LMM--low values of MM, IMM--intermediate values of MM, and HMM--high values of MM), 2 groups according to the values of femoral neck BMD (LFN--low values and HFN--high values), and 3 groups for trochanter BMD (LTR--low values, ITR--intermediate values, and HTR--high values). The results of Pearson chi-square revealed a significant association between femoral neck BMD and lower limb MM, and trochanter BMD and lower limb MM, suggesting that individuals with reduced lower limb MM are prone to have decreased femoral neck and trochanter BMD. The present study supports the hypothesis of a relation between the incidence of low BMD and MM. It is recommended that dual-energy X-ray absorptiometry screening should be used to identify both BMD and MM in postmenopausal women to assess more accurately the risk of fractures and disability.
衰老与多种生理变化相关，这些变化会导致残疾和死亡率增加。这些变化的例子包括骨骼和肌肉组织的退化，分别称为骨质减少和肌肉减少症。两者都与老年人的多种病态结局有关。本研究的主要目的是确定绝经后女性股骨颈和转子骨矿物质密度（BMD）与下肢非骨无脂肪质量（MM）之间的关联。189名绝经后女性自愿参与本研究（平均年龄66.92±5.23岁）。根据下肢MM、股骨颈和转子BMD测量值，使用两步聚类分析将受试者分为不同组。采用Pearson卡方检验分析BMD与MM分布之间的相关性。两步聚类分析根据下肢MM水平（LMM——MM低值、IMM——MM中间值、HMM——MM高值）形成3组，根据股骨颈BMD值（LFN——低值和HFN——高值）形成2组，根据转子BMD形成3组（LTR——低值、ITR——中间值、HTR——高值）。Pearson卡方检验结果显示，股骨颈BMD与下肢MM、转子BMD与下肢MM之间存在显著关联，表明下肢MM降低的个体股骨颈和转子BMD易于降低。本研究支持低BMD与MM发生率之间存在关联的假设。建议采用双能X线吸收法筛查绝经后女性的BMD和MM，以更准确地评估骨折和残疾风险。
