British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London W12 0NN, UK.
Clin Sci (Lond). 2010 Feb 23;118(10):593-605. doi: 10.1042/CS20090557.
Cardiovascular pathologies are still the primary cause of death worldwide. The molecular mechanisms behind these pathologies have not been fully elucidated. Unravelling them will bring us closer to therapeutic strategies to prevent or treat cardiovascular disease. One of the major transcription factors that has been linked to both cardiovascular health and disease is NF-kappaB (nuclear factor kappaB). The NF-kappaB family controls multiple processes, including immunity, inflammation, cell survival, differentiation and proliferation, and regulates cellular responses to stress, hypoxia, stretch and ischaemia. It is therefore not surprising that NF-kappaB has been shown to influence numerous cardiovascular diseases including atherosclerosis, myocardial ischaemia/reperfusion injury, ischaemic preconditioning, vein graft disease, cardiac hypertrophy and heart failure. The function of NF-kappaB is largely dictated by the genes that it targets for transcription and varies according to stimulus and cell type. Thus NF-kappaB has divergent functions and can protect cardiovascular tissues from injury or contribute to pathogenesis depending on the cellular and physiological context. The present review will focus on recent studies on the function of NF-kappaB in the cardiovascular system.
心血管疾病仍然是全球范围内的主要死亡原因。这些疾病背后的分子机制尚未完全阐明。揭示这些机制将使我们更接近预防或治疗心血管疾病的治疗策略。与心血管健康和疾病都有关联的主要转录因子之一是 NF-κB（核因子 κB）。NF-κB 家族控制着多种过程，包括免疫、炎症、细胞存活、分化和增殖，并调节细胞对应激、缺氧、拉伸和缺血的反应。因此，NF-κB 已被证明会影响多种心血管疾病，包括动脉粥样硬化、心肌缺血/再灌注损伤、缺血预处理、静脉移植物疾病、心脏肥大和心力衰竭，这并不奇怪。NF-κB 的功能在很大程度上取决于它针对转录的靶基因，并根据刺激和细胞类型而有所不同。因此，NF-κB 具有不同的功能，并且可以根据细胞和生理环境保护心血管组织免受损伤或有助于发病机制。本文综述将重点介绍 NF-κB 在心血管系统中的功能的最新研究。
