Su Mengzhu, Qiu Fanghui, Li Yansong, Che Tongtong, Li Ningning, Zhang Shuangshuang
Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China.
School of Physical Education, Qingdao University, Qingdao, China.
Front Cell Dev Biol. 2024 Sep 20;12:1464815. doi: 10.3389/fcell.2024.1464815. eCollection 2024.
Nicotinamide adenine dinucleotide (NAD) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses. Lower NAD levels have been associated with various diseases, highlighting the importance of replenishing NAD+. Nicotinamide phosphoribosyltransferase (NAMPT) plays a critical role in the NAD salvage pathway, which helps sustain NAD levels, particularly in high-energy tissues like skeletal muscle.This review explores how the NAMPT-driven NAD salvage pathway influences skeletal muscle health and functionality in aging, type 2 diabetes mellitus (T2DM), and skeletal muscle injury. The review offers insights into enhancing the salvage pathway through exercise and NAD boosters as strategies to improve muscle performance. The findings suggest significant potential for using this pathway in the diagnosis, monitoring, and treatment of skeletal muscle conditions.
烟酰胺腺嘌呤二核苷酸（NAD）对细胞能量产生至关重要，在氧化还原反应中作为辅酶发挥作用。它还支持参与DNA修复、衰老和免疫反应等过程的酶。较低的NAD水平与多种疾病有关，这凸显了补充NAD+的重要性。烟酰胺磷酸核糖基转移酶（NAMPT）在NAD补救途径中起关键作用，该途径有助于维持NAD水平，尤其是在骨骼肌等高能量组织中。本综述探讨了NAMPT驱动的NAD补救途径如何影响衰老、2型糖尿病（T2DM）和骨骼肌损伤中的骨骼肌健康和功能。该综述提供了通过运动和NAD增强剂增强补救途径的见解，作为改善肌肉性能的策略。研究结果表明，利用该途径进行骨骼肌疾病的诊断、监测和治疗具有巨大潜力。
