Institute of Dermatology, Medical Services, Bangkok, Thailand.
J Dermatol. 2010 Feb;37(2):140-5. doi: 10.1111/j.1346-8138.2009.00776.x.
The aim of the present study was to examine the effect of far erythemogenic dose of narrow-band ultraviolet B (NB-UVB; starting dose at 35% minimal erythematous dose [MED]) on clinical response by measuring the severity, extent of disease and the changes in quality of life. Fifty patients with chronic plaque-type psoriasis were enrolled. Therapy was held for 3 days a week. The severity of the disease was assessed based on the Psoriasis Area and Severity Index (PASI) score and Dermatology Life Quality Index (DLQI) scores. The percentage improvement of PASI at 30 sessions was 68.99%. The improvement in DLQI scores at 30 sessions was 79.67%. Pearson correlation coefficients showed that PASI scores were not correlated with DLQI scores at the beginning of treatment (P = 0.330, r = 0.14), but after the 30th session of NB-UVB therapy improvements in quality of life were correlated (P < 0.05, r = 0.399). Therefore, far erythemogenic dose of NB-UVB is considered to be effective treatment for plaque-type psoriasis in our patients. However, we cannot confirm that it is safer than higher MED starting dose in term of cumulative UV irradiation.
本研究旨在通过测量严重程度、疾病程度和生活质量的变化，来检查远红斑量窄谱中波紫外线（NB-UVB；起始剂量为 35%最小红斑量[MED]）对临床反应的影响。共有 50 名慢性斑块型银屑病患者入组。每周治疗 3 天。根据银屑病面积和严重程度指数（PASI）评分和皮肤病生活质量指数（DLQI）评分评估疾病严重程度。30 次治疗后 PASI 的改善率为 68.99%。30 次治疗后 DLQI 评分的改善率为 79.67%。Pearson 相关系数显示，治疗开始时 PASI 评分与 DLQI 评分之间无相关性（P = 0.330，r = 0.14），但在 NB-UVB 治疗的第 30 次后，生活质量的改善与 PASI 评分相关（P < 0.05，r = 0.399）。因此，我们认为远红斑量 NB-UVB 是治疗斑块型银屑病的有效方法。然而，我们不能确认与较高的 MED 起始剂量相比，远红斑量 NB-UVB 在累积紫外线照射方面更安全。
