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生物能量学与生物膜漫谈

Wanderings in bioenergetics and biomembranes.

作者信息

Klingenberg Martin

机构信息

Institut für Physiologische Chemie der Universität München, Schillerstr. 44, D-80336 München, Germany.

出版信息

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):579-94. doi: 10.1016/j.bbabio.2010.02.012. Epub 2010 Feb 20.

Abstract

Having worked for 55 years in the center and at the fringe of bioenergetics, my major research stations are reviewed in the following wanderings: from microsomes to mitochondria, from NAD to CoQ, from reversed electron transport to reversed oxidative phosphorylation, from mitochondrial hydrogen transfer to phosphate transfer pathways, from endogenous nucleotides to mitochondrial compartmentation, from transport to mechanism, from carrier to structure, from coupling by AAC to uncoupling by UCP, and from specific to general transport laws. These wanderings are recalled with varying emphasis paid to the covered science stations.

摘要

在生物能量学的核心和边缘领域工作了55年后,我在接下来的回顾中审视了我的主要研究站:从微粒体到线粒体,从烟酰胺腺嘌呤二核苷酸(NAD)到辅酶Q(CoQ),从逆向电子传递到逆向氧化磷酸化,从线粒体氢转移到磷酸转移途径,从内源性核苷酸到线粒体区室化,从转运到机制,从载体到结构,从腺苷酸转运体(AAC)介导的偶联到解偶联蛋白(UCP)介导的解偶联,以及从特定的转运规律到一般的转运规律。回顾这些历程时,对所涉及的各个科学领域的侧重点各有不同。

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