Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China.
Fitoterapia. 2010 Sep;81(6):595-9. doi: 10.1016/j.fitote.2010.02.002. Epub 2010 Feb 20.
Two new prenylated xanthones and a new prenylated tetrahydroxanthone, garcimangosxanthone A-C (1-3), along with fourteen known xanthones were isolated from the pericarp of Garcinia mangostana. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibited in vitro cytotoxicity against A549, LAC and A375 cell lines with IC(50) values of 5.7-24.9 microM, which were comparable to those of doxorubicin.
从山竹果皮中分离得到了两个新的二氢沉香呋喃酮和一个新的二氢苯并呋喃酮，即 Garcimangosxanthone A-C（1-3），以及 14 个已知的黄烷酮。根据光谱数据确定了它们的结构。化合物 1 和 2 对 A549、LAC 和 A375 细胞系表现出体外细胞毒性，IC50 值为 5.7-24.9 μM，与阿霉素相当。
