Ee Gwendoline Cheng Lian, Daud Shaari, Izzaddin Sheikh Ahmad, Rahmani Mawardi
Chemistry Department, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
J Asian Nat Prod Res. 2008 May-Jun;10(5-6):475-9. doi: 10.1080/10286020801948490.
Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds. The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone. Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), mangostanol (6), and garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2 microg/ml, respectively. This is the first report on the cytotoxicity of the extracts of the stem and root bark of G. mangostana and of alpha-mangostin, mangostanol, and garcinone D against the CEM-SS cell line.
我们目前从植物中寻找天然抗癌先导化合物的研究兴趣，使我们发现山竹的茎和根可能是这类化合物的来源。茎中分离出2,8 - 二羟基 - 6 - 甲氧基 - 5 - (3 - 甲基丁 - 2 - 烯基) - 呫吨酮(1)，这是一种新的呫吨酮。同时，该植物的根皮中分离出六种呫吨酮，即α - 倒捻子素(2)、β - 倒捻子素(3)、γ - 倒捻子素(4)、藤黄双黄酮D(5)、山竹醇(6)和藤黄宁(7)。发现山竹根皮的己烷和氯仿提取物以及茎皮的己烷提取物对CEM - SS细胞系具有活性。γ - 倒捻子素(4)表现出良好的活性，IC(50)值非常低，为4.7微克/毫升，而α - 倒捻子素(2)、山竹醇(6)和藤黄双黄酮D(5)分别表现出显著活性，IC(50)值为5.5、9.6和3.2微克/毫升。这是关于山竹茎皮和根皮提取物以及α - 倒捻子素、山竹醇和藤黄双黄酮D对CEM - SS细胞系细胞毒性的首次报道。
