Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. yanzi
J Ethnopharmacol. 2010 Apr 21;128(3):623-8. doi: 10.1016/j.jep.2010.02.003. Epub 2010 Feb 20.
The antithrombotic effect of Danggui and Honghua, herbs commonly used in Traditional Chinese medicine to treat the syndrome corresponding to vascular thrombosis, and their potential interactions with clopidogrel were investigated.
The efficacy of Danggui, Honghua alone or combination with clopidogrel was determined in three experimental models. Bleeding time and hematology parameters were measured to evaluate safety.
Danggui and Honghua exhibited antithrombotic effects against venous thrombosis and pulmonary embolism. Especially in the case of venous thrombosis, the thrombus weight was decreased significantly by Danggui or Honghua when compared with control. Bleeding time and coagulation time tended to be prolonged by Danggui or Honghua, but only prothrombin time (PT) and thrombin time (TT) were augmented significantly. The combinations of Danggui plus clopidogrel and of Honghua plus clopidogrel failed to significantly enhance the antithrombotic effects of clopidogrel alone against arterial thrombosis, venous thrombosis and pulmonary embolism. However, both Danggui and Honghua significantly potentiated the prolongation caused by clopidogrel on the tail bleeding time and PT.
Danggui and Honghua possess antithrombotic activity and cannot potentiate the antithrombotic effect of clopidogrel. However, they significantly enhance the deleterious effect of clopidogrel on bleeding time, PT and TT.
本研究旨在探讨当归和红花这两味常用于治疗血栓形成相应证候的中药的抗血栓作用，以及它们与氯吡格雷的潜在相互作用。
本研究采用三种实验模型来确定当归、红花单独使用或与氯吡格雷联合使用的疗效。通过测量出血时间和血液学参数来评估安全性。
当归和红花对静脉血栓形成和肺栓塞均具有抗血栓作用。特别是在静脉血栓形成的情况下，与对照组相比，当归或红花能显著降低血栓重量。当归或红花可使出血时间和凝血时间延长，但仅使凝血酶原时间（PT）和凝血酶时间（TT）显著延长。当归加氯吡格雷和红花加氯吡格雷的联合用药未能显著增强氯吡格雷单独对动脉血栓形成、静脉血栓形成和肺栓塞的抗血栓作用。然而，当归和红花均能显著增强氯吡格雷对尾出血时间和 PT 延长的作用。
当归和红花具有抗血栓活性，不能增强氯吡格雷的抗血栓作用。然而，它们能显著增强氯吡格雷对出血时间、PT 和 TT 的有害作用。
