Wu Jing, Zhang Mingjun
Department of Mechanical, Aerospace and Biomedical Engineering, The University of Tennessee, Knoxville, TN 37996-2210, USA.
IEEE Trans Syst Man Cybern B Cybern. 2010 Jun;40(3):694-702. doi: 10.1109/TSMCB.2010.2040616. Epub 2010 Feb 18.
For human immunodeficiency virus (HIV) infection treatment, the host immune system and antiviral drugs form a coalition to fight against HIV. Evidence suggests that drug therapy with Highly Active Antiretroviral Therapy can effectively prolong the life of the patient because it can reduce the replication of HIV while, at the same time, protecting the CD4+ T cells. The dosages of different drugs, however, are important in determining the success of the treatment. In addition, drug therapy for HIV is complicated by the fact that viruses can mutate, thereby effectively escaping from the attack of the drugs. This paper models HIV drug therapy by considering a game between HIV and a coalition consisting of both antiviral drugs and the host immune system. The Nash equilibrium (NE) is calculated as the solution of the game. The simulation results show that an NE exists in which both T cells and viruses remain and coexist after several generations. This brings a new drug therapy during HIV infection to prolong the life of the patient with HIV coexistence.
对于人类免疫缺陷病毒（HIV）感染的治疗，宿主免疫系统和抗病毒药物形成了对抗HIV的联盟。有证据表明，高效抗逆转录病毒疗法的药物治疗可以有效延长患者的生命，因为它可以减少HIV的复制，同时保护CD4 + T细胞。然而，不同药物的剂量对于确定治疗的成功至关重要。此外，HIV的药物治疗因病毒会发生变异从而有效逃避药物攻击这一事实而变得复杂。本文通过考虑HIV与由抗病毒药物和宿主免疫系统组成的联盟之间的博弈来模拟HIV药物治疗。计算纳什均衡（NE）作为博弈的解。模拟结果表明存在一种NE，其中T细胞和病毒在几代之后仍然存在并共存。这为HIV感染期间的药物治疗带来了新方法，以在HIV共存的情况下延长患者的生命。
