From the Department of Obstetrics and Gynecology, The University of Chicago; and Department of Family Medicine, University of Illinois at Chicago, Illinois.
Obstet Gynecol. 2010 Mar;115(3):503-510. doi: 10.1097/AOG.0b013e3181cf45dc.
To compare satisfaction with and adherence to the contraceptive vaginal ring and a daily low-dose oral contraceptive pill (OCP) among college and graduate students using a novel method of electronic data collection.
We randomly assigned 273 women to the contraceptive vaginal ring (n=136) or OCP (n=137) for three consecutive menstrual cycles. Participants completed daily Internet-based, online diaries regarding method adherence and satisfaction during cycles of use. At 3 months, they completed an online survey regarding intention to continue their method and overall acceptability. At 6 months, we surveyed participants to see whether they continued using contraception and, if so, which method.
Rates of loss to follow-up were similar between groups. Contraceptive vaginal ring users reported more perfect use in the first 2 months (P=.05). After the 3-month study period, 52 (43%) of 121 contraceptive vaginal ring users and 65 (52%) of 126 OCP users reported plans to continue their method (P=.16). However, at 6 months, only 31 (26%) of 117 contraceptive vaginal ring users and 36 (29%) of 123 OCP users had continued their assigned study method (P=.61). Almost 50% of both groups were using condoms or no method.
Contraceptive vaginal ring users were more likely to report perfect use during the 3-month trial period than were OCP users. Despite randomization, participants were equally satisfied with their assigned hormonal contraceptive method. At 6 months, less than 30% of participants were still using their assigned method.
ClinicalTrials.gov, www.clinicaltrials.gov, NCT00635570.
采用一种新的电子数据收集方法，比较大学生和研究生使用避孕阴道环和每日低剂量口服避孕药（OCP）的满意度和依从性。
我们将 273 名女性随机分配至避孕阴道环（n=136）或 OCP（n=137）组，连续使用三个月经周期。参与者在使用周期内每天通过互联网在线日记记录方法的依从性和满意度。在 3 个月时，他们完成了一项关于继续使用其方法的意愿和总体可接受性的在线调查。在 6 个月时，我们调查了参与者是否继续使用避孕措施，如果是，使用哪种方法。
两组的失访率相似。避孕阴道环使用者在前 2 个月报告的完美使用率更高（P=.05）。在 3 个月的研究期后，52（43%）名 121 名避孕阴道环使用者和 65（52%）名 126 名 OCP 使用者报告计划继续使用其方法（P=.16）。然而，在 6 个月时，只有 31（26%）名 117 名避孕阴道环使用者和 36（29%）名 123 名 OCP 使用者继续使用其指定的研究方法（P=.61）。两组几乎有 50%的人使用避孕套或不使用任何方法。
与 OCP 使用者相比，在 3 个月的试验期间，避孕阴道环使用者更有可能报告完美使用。尽管进行了随机分组，但参与者对其指定的激素避孕方法均满意。在 6 个月时，不到 30%的参与者仍在使用其指定的方法。
ClinicalTrials.gov，www.clinicaltrials.gov，NCT00635570。
