Obstet Gynecol. 2010 Mar;115(3):669-671. doi: 10.1097/AOG.0b013e3181d4ffa5.
Numerous large clinical studies have evaluated the evidence regarding magnesium sulfate, neuroprotection, and preterm births. The Committee on Obstetric Practice and the Society for Maternal-Fetal Medicine recognize that none of the individual studies found a benefit with regard to their primary outcome. However, the available evidence suggests that magnesium sulfate given before anticipated early preterm birth reduces the risk of cerebral palsy in surviving infants. Physicians electing to use magnesium sulfate for fetal neuroprotection should develop specific guidelines regarding inclusion criteria, treatment regimens, concurrent tocolysis, and monitoring in accordance with one of the larger trials.
大量大型临床研究评估了硫酸镁、神经保护和早产的证据。产科实践委员会和母胎医学学会认识到，没有一项单独的研究在其主要结局方面发现获益。然而，现有证据表明，在预计的早期早产前给予硫酸镁可降低存活婴儿脑瘫的风险。选择使用硫酸镁进行胎儿神经保护的医生应根据较大型试验之一制定具体的纳入标准、治疗方案、同时保胎和监测指南。
