Gottesfeld Joel M, Pandolfo Massimo
Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA, Tel.: +1 858 784 8913.
Future Neurol. 2009 Nov 1;4(6):775-784. doi: 10.2217/fnl.09.55.
Postsynthetic modifications of histone and other chromosomal proteins by reversible acetylation and/or methylation regulate many aspects of chromatin dynamics, such as transcription, replication and DNA repair. Aberrant modification states are associated with several neurological and neuromotor diseases. Thus, small molecules that inhibit or activate the enzymes responsible for these chromatin modifications have received considerable attention as potential human therapeutics. This paper summarizes the current state of development of histone deacetylase inhibitors in a variety of neurological diseases.
组蛋白和其他染色体蛋白通过可逆的乙酰化和/或甲基化进行的合成后修饰调节染色质动力学的许多方面，如转录、复制和DNA修复。异常的修饰状态与多种神经和神经运动疾病相关。因此，抑制或激活负责这些染色质修饰的酶的小分子作为潜在的人类治疗药物受到了广泛关注。本文总结了组蛋白脱乙酰酶抑制剂在多种神经疾病中的当前发展状况。
