酰胺官能化二茂钛的合成、结构与生物活性：改善其细胞毒性特性
Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties.
作者信息
Gao Li Ming, Matta Jaime, Rheingold Arnold L, Meléndez Enrique
机构信息
Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681.
出版信息
J Organomet Chem. 2009 Dec 15;694(26):4134-4139. doi: 10.1016/j.jorganchem.2009.09.016.
Abstract
Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.
摘要
已合成了九种酰胺官能化二茂钛，并通过光谱和分析方法对其进行了表征，且通过单晶X射线衍射确定了Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2)的固态结构。对Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2)的X射线分析表明，钛处于假四面体几何构型，且含有Ti-O(酰胺)配位。原则上，与二氯二茂钛相比，Ti-O配位应为相应的二茂钛基提供更高的水解稳定性。通过MTT法测定了这些酰胺官能化二茂钛对HT-29结肠癌细胞系的细胞毒性活性，以阐明构效关系。所有配合物的细胞毒性均比二氯二茂钛更强，且苯环上的对位取代基与其细胞毒性之间没有相关性。
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