片剂制剂中富马酸酮替芬的分光光度法测定。
Spectrophotometric estimation of ketotifen fumarate from tablet formulations.
作者信息
Singhvi I, Sachdeva D
机构信息
Pacific College of Pharmacy, Pacific Hills, Pratap Nagar, Air-port Road, Udaipur-313 001, India.
出版信息
Indian J Pharm Sci. 2009 Jan;71(1):66-8. doi: 10.4103/0250-474X.51964.
Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and rhodizonic acid. The extracted complex of drug with 2-nitroso- napthol-4- sulphonic acid (method-I), showed absorbance maxima at 436.5 nm and with rhodizonic acid (method-II), showed absorbance maxima at 489.5 nm. The linearity range for both the developed methods was observed in the concentration range of 50-250 microg/ml of drug. Results of analysis for both the developed methods were validated statistically and by recovery studies.
已开发出两种简单且灵敏的可见分光光度法，用于从富马酸酮替芬片剂配方中对其进行定量测定。所开发的方法基于富马酸酮替芬与2-亚硝基萘酚-4-磺酸和玫瑰红酸形成可被氯仿萃取的有色络合物。药物与2-亚硝基萘酚-4-磺酸形成的萃取络合物（方法-I）在436.5 nm处有最大吸收，与玫瑰红酸形成的萃取络合物（方法-II）在489.5 nm处有最大吸收。两种所开发方法的线性范围在药物浓度为50 - 250微克/毫升内。两种所开发方法的分析结果通过统计学和回收率研究进行了验证。
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