用于提高恩诺沙星溶解度的各种溶剂系统。
Various solvent systems for solubility enhancement of enrofloxacin.
作者信息
Seedher Neelam, Agarwal Pooja
机构信息
Department of Chemistry, Panjab University, Chandigarh-160 014, India.
出版信息
Indian J Pharm Sci. 2009 Jan;71(1):82-7. doi: 10.4103/0250-474X.51958.
Abstract
Solubility enhancement of antimicrobial drug enrofloxacin has been studied using a series of co-solvents and surfactants. Aqueous solubility of enrofloxacin could be increased up to 26 times. Co-solvents alone produced only small increase in solubility. However, the combined effect of co-solvents and buffer was synergistic and a large increase in solubility could be attained. Ionic surfactants were found to be much better solubilizing agents than non-ionic surfactant. Amongst ionic surfactants, solubility was found to be very high in anionic surfactant, sodium dodecylsulphate as compared to the cationic surfactant, cetyltrimethylammonium bromide. Up to 3.8 mg/ml of enrofloxacin could be dissolved in sodium dodecylsulphate. Mechanism of solubilization has been proposed and surfactant solubilization parameters have been calculated.
摘要
使用一系列助溶剂和表面活性剂研究了抗菌药物恩诺沙星的溶解度增强情况。恩诺沙星的水溶性可提高至26倍。单独使用助溶剂时溶解度仅略有增加。然而，助溶剂和缓冲剂的联合作用具有协同性，可实现溶解度的大幅提高。发现离子型表面活性剂比非离子型表面活性剂具有更好的增溶作用。在离子型表面活性剂中，与阳离子表面活性剂十六烷基三甲基溴化铵相比，阴离子表面活性剂十二烷基硫酸钠的溶解度非常高。在十二烷基硫酸钠中可溶解高达3.8 mg/ml的恩诺沙星。提出了增溶机制并计算了表面活性剂增溶参数。
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