Desai N C, Bhavsar A M, Baldaniya B B
Medicinal Chemistry Division, University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002, India.
Indian J Pharm Sci. 2009 Jan;71(1):90-4. doi: 10.4103/0250-474X.51953.
Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of OH, OCH(3), NO(2), Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.
制备了几种4-亚芳基-2-苯基-1-(2,4,5-三氯苯基)-1H-咪唑-5(4H)-酮(4a-q)、N-(4-亚苄基-5-氧代-2-苯基-4,5-二氢咪唑-1-基)-4-氯苯甲酰胺(5a-o)和N-(4-亚苄基-5-氧代-2-苯基-4,5-二氢咪唑-1-基)-2,4-二氯苯甲酰胺(6a-m)。所有新合成的化合物均已针对革兰氏阳性菌和革兰氏阴性菌以及不同的真菌菌株进行了抗菌活性测试。在杂环骨架中引入OH、OCH(3)、NO(2)、Cl和Br基团可增强抗菌和抗真菌活性。
