• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Antiparkinsonian activity and dopamine receptor binding studies of imidazolone derivatives.

作者信息

Naithani P K, Srivastava V K, Saxena A K, Barthwal J P, Gupta T K, Shanker K

机构信息

Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.

出版信息

Indian J Exp Biol. 1990 Dec;28(12):1145-8.

PMID:2099330
Abstract

Mannich bases and styryl derivatives of imidazolones were evaluated for their antiparkinsonian activity. Two compounds showed potent antiparkinsonian activity. These active compounds also showed binding with dopamine receptors in striatal membrane preparation of rat brain.

摘要

相似文献

1
Antiparkinsonian activity and dopamine receptor binding studies of imidazolone derivatives.
Indian J Exp Biol. 1990 Dec;28(12):1145-8.
2
Dopamine receptor binding activity of anti-parkinsonian active piperazino derivatives.抗帕金森病活性哌嗪衍生物的多巴胺受体结合活性
Indian J Exp Biol. 1988 Jan;26(1):15-7.
3
Further characterization of structural requirements for agonists at the striatal dopamine D2 receptor and a comparison with those at the striatal dopamine D1 receptor. Studies with a series of monohydroxyaminotetralins on acetylcholine release from rat striatum.纹状体多巴胺D2受体激动剂结构要求的进一步表征及其与纹状体多巴胺D1受体激动剂结构要求的比较。用一系列单羟基氨基四氢萘对大鼠纹状体乙酰胆碱释放的研究。
Mol Pharmacol. 1984 Nov;26(3):452-7.
4
Dopamine receptor binding of a novel dibenzodioxazocine derivative, EGYT-2509.
Pol J Pharmacol Pharm. 1985 May-Jun;37(3):253-61.
5
[35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents.以[35S]鸟苷-5'-O-(3-硫代)三磷酸结合作为衡量人重组多巴胺D4.4受体效能的指标：抗帕金森病药和抗精神病药的作用
J Pharmacol Exp Ther. 1997 Jul;282(1):181-91.
6
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.作为选择性5-羟色胺3（5-HT3）受体拮抗剂的苯基咪唑烷-2-酮衍生物及5-HT3受体结合药效团模型的优化
J Med Chem. 1997 Oct 10;40(21):3369-80. doi: 10.1021/jm970060o.
7
Synthesis and dopamine receptor binding of 4-(2-aminoethyl)-1H-pyrazole and its N,N-dialkyl derivatives.
Drug Des Discov. 1993;10(1):57-64.
8
Dopaminergic activity of the antimuscarinic antiparkinsonian agents.抗胆碱能抗帕金森病药物的多巴胺能活性。
J Clin Psychopharmacol. 1989 Oct;9(5):347-51.
9
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.新型N-杂芳基5/6-环曼尼希碱的设计、合成及多巴胺D4受体结合活性
Bioorg Med Chem. 2009 Jul 1;17(13):4448-58. doi: 10.1016/j.bmc.2009.05.015. Epub 2009 May 12.
10
Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity in mice.作为多巴胺能配体的四氢异喹啉：1-丁基-7-氯-6-羟基-四氢异喹啉，一种在小鼠中具有类抗抑郁活性的新化合物。
Bioorg Med Chem. 2009 Jul 15;17(14):4968-80. doi: 10.1016/j.bmc.2009.05.079. Epub 2009 Jun 6.

引用本文的文献

1
Bis(1-benzyl-1H-benzimidazole-κN (3))di-chlorido-zinc.双(1-苄基-1H-苯并咪唑-κN(3))二氯合锌
Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 12;70(Pt 3):m94-5. doi: 10.1107/S1600536814002840. eCollection 2014 Mar 1.
2
Synthesis and antimicrobial activity of 5-imidazolinone derivatives.5-咪唑啉酮衍生物的合成与抗菌活性
Indian J Pharm Sci. 2009 Jan;71(1):90-4. doi: 10.4103/0250-474X.51953.