Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala - 147 002, India.
Indian J Pharmacol. 2009 Feb;41(1):15-8. doi: 10.4103/0253-7613.48885.
The present study was designed to investigate the anticonvulsant potential of nickel which is shown to selectively block t-type calcium channels by using nickel choride on pentylenetetrazole (80 mg/kg) induced seizure activity model in mice.
Seizures were assessed in terms of onset of Straub's tail phenomenon and onset of jerky movements of the whole body, convulsions, and death. Sodium valproate served as a standard control in the present study.
Nickel chloride (5 mg/kg i.p. and 10 mg/kg i.p.) attenuated pentylenetetrazole-induced seizure activity in mice, as reflected by a significant increase in the onset time of Straub's tail phenomenon and onset of jerky movements of the whole body, convulsions, and death. High dose of nickel chloride showed more pronounced anticonvulsant action than sodium valproate.
The anticonvulsant action of nickel chloride was noticeable in this study. However, further studies are required to elucidate its full anticonvulsant potential.
本研究旨在通过氯化镍对戊四氮（80mg/kg）诱导的小鼠癫痫发作模型的作用，研究镍的抗惊厥潜力，镍被证明可选择性地阻断 T 型钙通道。
以 Straub 尾巴现象的开始和整个身体的抽搐运动的开始、抽搐和死亡为指标评估癫痫发作。本研究中，丙戊酸钠作为标准对照。
氯化镍（腹腔注射 5mg/kg 和 10mg/kg）可减轻戊四氮诱导的小鼠癫痫发作活动，表现为 Straub 尾巴现象的开始和整个身体的抽搐运动的开始、抽搐和死亡时间明显延长。高剂量的氯化镍显示出比丙戊酸钠更明显的抗惊厥作用。
本研究中观察到氯化镍的抗惊厥作用。然而，需要进一步的研究来阐明其全部的抗惊厥潜力。
