Department of Pharmacology, Kasturba Medical College, Madhav Nagar, Manipal, Karnataka, India.
Indian J Pharmacol. 2009 Feb;41(1):49-50. doi: 10.4103/0253-7613.48883.
Olanzapine, an atypical antipsychotic is considered superior to its conventional congeners. Here we report two cases of pedal edema secondary to olanzapine. In both cases the systemic causes of pedal edema were ruled out. On reducing the dose of olanzapine, pedal edema regressed and completely resolved after stopping the drug. So we attribute the edema to olanzapine therapy. As the definitive cause and further consequences of pedal edema are not known, hence stringent monitoring of adverse effects of this drug is required.
奥氮平是一种新型抗精神病药，被认为优于传统同类药物。本文报告两例奥氮平引起的足踝部水肿。这两例均已排除全身性水肿的原因。减少奥氮平剂量后，水肿消退，停药后完全缓解。故我们认为水肿是由奥氮平引起的。由于目前还不知道足踝部水肿的确切原因和进一步的后果，因此需要严格监测这种药物的不良反应。
