Vijayaraghavan R, Rao S S, Suryanarayana M V, Swamy R V
Defence Research and Development Establishment, Gwalior, India.
Toxicology. 1991 Mar 25;67(1):85-96. doi: 10.1016/0300-483x(91)90166-x.
N,N-Diethylphenylacetamide (DEPA) is an inexpensive, long-acting and broad spectrum insect repellent. The acute LC50 for a 4-h exposure of DEPA aerosol was found to be 1.451 mg l-1 (1.290-1.633) in male and 1.375 mg l-1 (1.307-1.447) in female rats. DEPA did not cause delayed deaths. Acute exposure to 0.9 LC50 revealed that liver might be a target organ for DEPA toxicity. On subacute exposures to 0.2, 0.6 and 0.8 LC50 for 6 h per day, 5 days a week for 2 weeks, there was no significant change in the 0.2 LC50 group, as evaluated by the body weight gain and organ body weight ratio. The minimal changes observed in the 0.6 LC50 group were of reversible type as the animals recovered on cessation of exposure. A massive concentration of 0.8 LC50 produced lethal effects. The study shows that DEPA has a low mammalian toxicity by inhalation as was found earlier with cutaneous application of the insect repellent.
N,N-二乙基苯乙酰胺（DEPA）是一种价格低廉、长效且广谱的驱虫剂。在雄性大鼠中，DEPA气雾剂4小时暴露的急性半数致死浓度（LC50）为1.451毫克/升（1.290 - 1.633），在雌性大鼠中为1.375毫克/升（1.307 - 1.447）。DEPA不会导致延迟死亡。急性暴露于0.9 LC50表明，肝脏可能是DEPA毒性的靶器官。在亚急性暴露中，每天6小时、每周5天、持续2周暴露于0.2、0.6和0.8 LC50，通过体重增加和器官体重比评估，0.2 LC50组没有显著变化。在0.6 LC50组中观察到的最小变化是可逆的，因为动物在停止暴露后恢复了。0.8 LC50的高浓度产生了致死效应。该研究表明，正如早期发现的该驱虫剂经皮肤应用时一样，DEPA通过吸入对哺乳动物的毒性较低。
