Angadi Punnya V, Rao Sanjay
KLE VK institute of Dental Sciences and Hospital, J.N.M.C. Campus, Nehrunagar, Belgaum, 590010, Karnataka State, India.
Oral Maxillofac Surg. 2010 Sep;14(3):133-42. doi: 10.1007/s10006-010-0209-x.
Oral submucous fibrosis is a disease due to a chronic, insidious change in fibroelasticity, characterized by burning sensation in the oral cavity, blanching, and stiffening of the oral mucosa and oro-pharynx leading to trismus and inability to open the mouth. The symptoms and signs depend on the progression of the lesions and number of affected sites. It is predominantly seen in Indians and other Asians. Once, the disease has developed, there is neither regression nor any effective treatment. It is considered as a pre-malignant stage of oral cancer and reported risk of malignant transformation varies from 2.3-7.6%.The common etiological factor considered for this unremitting disease is use of areca nut; however, the precise pathogenesis still remains elusive and controversial. A wide range of treatment consisting of drug management, surgical therapy, and physiotherapy have been attempted till date; with varying degrees of benefit, but none of them have proved to be a cure for this disease. This field remains open for clinical trials and research. This paper aims to provide an overview on various management modalities available for oral submucous fibrosis.
口腔黏膜下纤维化是一种由于纤维弹性发生慢性、隐匿性改变而导致的疾病，其特征为口腔内有烧灼感、口腔黏膜和口咽黏膜变白及变硬，进而导致牙关紧闭和张口困难。症状和体征取决于病变的进展及受累部位的数量。该病主要见于印度人和其他亚洲人。一旦疾病发展，既不会消退，也没有任何有效的治疗方法。它被认为是口腔癌的癌前阶段，报道的恶变风险为2.3%-7.6%。导致这种难治性疾病的常见病因是槟榔的使用；然而，确切的发病机制仍然难以捉摸且存在争议。迄今为止，已经尝试了包括药物治疗、手术治疗和物理治疗在内的多种治疗方法；疗效各异，但均未被证明能治愈这种疾病。该领域仍有待进行临床试验和研究。本文旨在概述口腔黏膜下纤维化现有的各种治疗方式。
