Bishop-Bailey David
Queen Mary University of London, Translational Medicine & Therapeutics, William Harvey Research Institute, Charterhouse Square, London, EC1M6BQ, UK.
Curr Opin Investig Drugs. 2010 Mar;11(3):283-8.
The PPARs are a family of three ligand-activated nuclear receptors: PPARalpha, PPARbeta/delta and PPARgamma. During the past 20 years, PPARs have been recognized as having important roles in the regulation of glucose and fatty acid metabolism, cell differentiation and immune function. In addition, all of the PPARs have been demonstrated to be expressed in the heart. The use of selective ligands, as well as certain conditional knockout and transgenic mouse models, has enabled the direct and indirect roles of PPARs in the regulation of fatty acid and glucose metabolism, hypertrophy, lipotoxicity, inflammation, and the circadian control of blood pressure and heart rate to be determined. This review discusses the evidence for the functions of PPARs as well as the new and emerging roles of PPAR pathways in cardiac structure and function.
过氧化物酶体增殖物激活受体（PPARs）是由三个配体激活的核受体组成的家族：PPARα、PPARβ/δ和PPARγ。在过去20年中，PPARs已被公认为在葡萄糖和脂肪酸代谢、细胞分化及免疫功能的调节中发挥重要作用。此外，所有PPARs均已证实在心脏中表达。选择性配体的使用，以及某些条件性基因敲除和转基因小鼠模型，使得PPARs在脂肪酸和葡萄糖代谢、肥大、脂毒性、炎症以及血压和心率的昼夜节律控制中的直接和间接作用得以确定。本综述讨论了PPARs功能的证据以及PPAR信号通路在心脏结构和功能中的新出现的作用。
