Fujii Hiroshi
Division of Molecular and Cellular Biology, Department of Signal Transduction Research, Niigata University, Graduate School of Medical and Dental Sciences.
Nihon Rinsho. 2005 Apr;63(4):565-71.
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPARs consist of three isotypes named PPARalpha (NR1C1), PPARbeta/delta (NR1C2) and PPARgamma (NR1C3) in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. Although each isotype fulfills distinct functions, PPARs function not only as an important fatty acid sensor that regulate lipid, carbohydrate and amino acid metabolism but also play an important role in various signaling pathways (immunity, inflammation, apoptosis and cell differentiation). In this review, I focus on emerging knowledge about PPARs roles in various intracellular signaling pathways.
过氧化物酶体增殖物激活受体（PPARs）是一类核激素受体，可被脂肪酸及其衍生物激活。在脊椎动物中，PPARs由三种亚型组成，分别命名为PPARα（NR1C1）、PPARβ/δ（NR1C2）和PPARγ（NR1C3）。它们各自由一个独立的基因编码，并与脂肪酸和类二十烷酸结合。尽管每种亚型都有不同的功能，但PPARs不仅作为调节脂质、碳水化合物和氨基酸代谢的重要脂肪酸传感器发挥作用，还在各种信号通路（免疫、炎症、凋亡和细胞分化）中发挥重要作用。在这篇综述中，我将重点关注PPARs在各种细胞内信号通路中作用的最新知识。
