Harvard Medical School, USA bJoslin Diabetes Center, Boston, Massachusetts 02215, USA.
Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):113-9. doi: 10.1097/MED.0b013e3283372859.
To review the association between vitamin D deficiency and diabetes and cardiovascular risk.
Vitamin D deficiency is newly recognized as a common condition of increasing prevalence worldwide. Clinically, vitamin D has an established role in calcium and bone metabolism and has recently been shown to be associated with increased risk of developing type 1 and type 2 diabetes mellitus and cardiovascular disease (CVD), as well as with cardiovascular risk factors such as hypertension and obesity. The molecular mechanisms of these associations remain incompletely understood. The active metabolite of vitamin D regulates transcription of multiple gene products with antiproliferative, prodifferentiative, and immunomodulatory effects. Although vitamin D deficiency is frequently unrecognized clinically, laboratory measurement is easy to perform and treatment of vitamin D deficiency is relatively well tolerated and inexpensive. Limited, yet promising, results of proof-of-concept intervention studies of using vitamin D in diabetes will be presented.
The high prevalence of vitamin D deficiency and plausible molecular mechanisms linking this to diabetes and cardiovascular risk suggest treatment of vitamin D deficiency to prevent and/or treat diabetes is a promising field to explore.
探讨维生素 D 缺乏与糖尿病和心血管风险的关系。
维生素 D 缺乏是一种新出现的、全球发病率不断上升的常见疾病。临床上，维生素 D 对钙和骨骼代谢具有明确的作用，最近的研究表明，维生素 D 缺乏与 1 型和 2 型糖尿病以及心血管疾病（CVD）的发病风险增加有关，同时还与高血压和肥胖等心血管危险因素有关。这些关联的分子机制尚不完全清楚。维生素 D 的活性代谢物调节多种基因产物的转录，具有抗增殖、促进分化和免疫调节作用。尽管维生素 D 缺乏在临床上常常未被识别，但实验室检测很容易进行，且维生素 D 缺乏的治疗相对耐受良好且费用低廉。本文将介绍一些使用维生素 D 治疗糖尿病的概念验证干预研究的有限但有前景的结果。
维生素 D 缺乏的高发病率以及将其与糖尿病和心血管风险联系起来的合理分子机制表明，治疗维生素 D 缺乏以预防和/或治疗糖尿病是一个很有前途的探索领域。
