Parsons K R, Bland A P, Hall G A
Institute for Animal Health, Compton Laboratory, Newbury, Berkshire.
Vet Pathol. 1991 Jan;28(1):22-9. doi: 10.1177/030098589102800104.
The morphology of the gut-associated lymphoid tissue of the small and large intestine in three gnotobiotic calves was examined by scanning and transmission electron microscopy, and the distribution of specialized membranous cells present in the follicle associated epithelium was defined. Isolated follicles remaining in the ileum of a cow after involution of the continuous Peyer's patch were examined by scanning electron microscopy. The presence of membrane-bound particles, reported to be exclusively associated with the continuous Peyer's patch, was investigated in other gut-associated tissue of the small and large intestine of the calf. The presence of two types of follicle associated epithelium in the small intestine of the calf was confirmed, and the follicle associated epithelium of the large intestine proved to be a homogeneous population of specialized membranous cells, similar to that of the continuous Peyer's patch of the small intestine. In the discrete Peyer's patches, some specialized membranous cells were completely hidden by adjacent enterocytes and could only be identified by cytoplasmic extensions into the intestinal lumen. In the proximal part of the continuous Peyer's patch, a transitional zone was detected where the follicle associated epithelium of some doomed villi was composed of a homogeneous population of specialized membranous cells, while the epithelium covering other doomed villi consisted of a mixture of absorptive and specialized membranous cells, usually only found in the discrete Peyer's patches. Membrane-bound particles were observed associated with gut-associated lymphoid tissue in the small and large intestine.
通过扫描电子显微镜和透射电子显微镜检查了三头无菌犊牛小肠和大肠中与肠道相关的淋巴组织的形态，并确定了存在于滤泡相关上皮中的特殊膜细胞的分布。通过扫描电子显微镜检查了一头母牛连续派尔集合淋巴结退化后回肠中残留的孤立滤泡。在犊牛小肠和大肠的其他与肠道相关的组织中，研究了据报道仅与连续派尔集合淋巴结相关的膜结合颗粒的存在情况。证实了犊牛小肠中存在两种类型的滤泡相关上皮，并且大肠的滤泡相关上皮被证明是一群同质的特殊膜细胞，类似于小肠连续派尔集合淋巴结的滤泡相关上皮。在离散的派尔集合淋巴结中，一些特殊膜细胞完全被相邻的肠上皮细胞掩盖，只能通过延伸到肠腔的细胞质来识别。在连续派尔集合淋巴结的近端部分，检测到一个过渡区，其中一些注定要退化的绒毛的滤泡相关上皮由一群同质的特殊膜细胞组成，而覆盖其他注定要退化的绒毛的上皮由吸收性细胞和特殊膜细胞混合组成，通常仅在离散的派尔集合淋巴结中发现。在小肠和大肠的与肠道相关的淋巴组织中观察到了膜结合颗粒。
