Soifer Luis, Peralta Angel Daniel, Arenoso Héctor, Caruso Norberto, Naisberg Gabriela
UNIMOT (Unidad de Motilidad y Patología Funcional Digestiva) - CABA, Argentina.
Acta Gastroenterol Latinoam. 2009 Dec;39(4):261-6.
The combination of omeprazole, sodium bicarbonate and alginic acid protects omeprazole from acid degradation and enhances the speed of action of the proton pump inhibitors.
To assess acid suppression capacity and speed of action of an oral powder combination (omeprazole 20 mg, sodium bicarbonate 1680 mg and alginic acid 250.08 mg) in healthy subjects, using gastric 24 h pHmetry.
Gastric 24 h pHmetry was performed in 13 healthy subjects on days 0 and 6. During the first pHmetry, 7 subjects received the combination 2 h before the end of the procedure. The second study was performed after the subjects had been administered the medication for the six previous days. The measurements were: a) time with pH < 4, b) time to reach maximum pH value, and c) pH peak after first drug administration.
The percentage of time with pH < 4 was 72.02 +/- 20.18 in the first study and 34.05 +/- 20.50 in the second (p < 0.01). Maximum pH obtained after first drug administration was 6.98 +/- 1.66 and the time to reach the pH peak was 18.34 +/- 9.84 minutes.
This oral powder combination induces significant, fast and intensive gastric acid suppression. Unlike delayed-release proton pump inhibitors, this product provides a faster but equally sustained control of gastric acidity.
奥美拉唑、碳酸氢钠和海藻酸的组合可保护奥美拉唑不被胃酸降解，并提高质子泵抑制剂的起效速度。
通过24小时胃pH监测，评估一种口服粉剂组合（奥美拉唑20毫克、碳酸氢钠1680毫克和海藻酸250.08毫克）在健康受试者中的抑酸能力和起效速度。
在第0天和第6天对13名健康受试者进行24小时胃pH监测。在第一次pH监测期间，7名受试者在检查结束前2小时服用该组合药物。第二次研究在受试者连续服用该药物六天后进行。测量指标包括：a）pH值<4的时间；b）达到最大pH值的时间；c）首次给药后的pH峰值。
在第一项研究中，pH值<4的时间百分比为72.02±20.18，在第二项研究中为34.05±20.50（p<0.01）。首次给药后获得的最大pH值为6.98±1.66，达到pH峰值的时间为18.34±9.84分钟。
这种口服粉剂组合可引起显著、快速且强烈的胃酸抑制。与缓释质子泵抑制剂不同，该产品能更快且同样持久地控制胃酸度。
