Atlanta Veterans Affairs Medical Center, Decatur, Atlanta, Georgia, USA.
Clin Infect Dis. 2010 Apr 1;50(7):1000-5. doi: 10.1086/651078.
The incidence of herpes zoster in the United States has been estimated to be > or =1 million cases annually, with a higher rate in adults older than 60 years. The morbidity of the disease, including postherpetic neuralgia, imposes significant effects on quality of life. We analyzed reports of herpes zoster in the Veterans Affairs (VA) population because these patients are older and could provide a reflection of disease trends in the aging US population. These data will provide a baseline for future analyses of the incidence of herpes zoster after the introduction of the herpes zoster vaccine in late 2007.
To evaluate the trend in the annual incidence of herpes zoster for fiscal year 2000 (beginning October 1999) through fiscal year 2007 (through September 2007), we derived incidence rates using the Veterans Health Administration Decision Support System reports of herpes zoster by International Classification of Diseases, Ninth Revision codes from 2000 through 2007 and the corresponding denominator data for all veterans in care. These rates were validated by review of medical records of patients with diagnoses of herpes zoster at the Atlanta VA Medical Center.
The annual incidence of herpes zoster increased from 3.10 episodes per 1000 veterans in 2000 to 5.22 in 2007 (R(2)=0.9743; P<.001). This increasing rate was seen in both men and women but only in groups older than 40 years.
The increasing incidence of herpes zoster in our veteran population and its effect on the quality of life of the veterans validate the need for improved rates of vaccination in this population.
据估计,美国带状疱疹的发病率每年>或=100 万例,60 岁以上成年人的发病率更高。该疾病的发病率,包括带状疱疹后神经痛,对生活质量造成了重大影响。我们分析了退伍军人事务部(VA)人群中带状疱疹的报告,因为这些患者年龄较大,可以反映美国老龄化人口中疾病趋势。这些数据将为 2007 年底带状疱疹疫苗推出后带状疱疹发病率的未来分析提供基线。
为了评估 2000 财年(1999 年 10 月开始)至 2007 财年(截至 2007 年 9 月)期间带状疱疹年发病率的趋势,我们使用退伍军人健康管理局决策支持系统报告的带状疱疹发病率,该系统通过国际疾病分类,第九版代码从 2000 年到 2007 年,并对所有在护理中的退伍军人进行相应的分母数据。这些比率通过亚特兰大退伍军人事务医疗中心诊断为带状疱疹的患者病历审查进行验证。
带状疱疹的年发病率从 2000 年的每 1000 名退伍军人 3.10 例增加到 2007 年的 5.22 例(R²=0.9743;P<.001)。这种增长趋势在男性和女性中都有,但只在 40 岁以上的人群中。
我们的退伍军人人群中带状疱疹发病率的增加及其对退伍军人生活质量的影响证明了在该人群中提高疫苗接种率的必要性。