Laboratory of Exercise Physiology, Department of Physical Education, College of Sports Science, Dong-A University, Busan, Korea.
Acta Paediatr. 2010 Aug;99(8):1263-8. doi: 10.1111/j.1651-2227.2010.01736.x. Epub 2010 Feb 22.
The objectives of this study are to assess the effects of a low-intensity exercise training which is not risky for children with type 1 diabetes mellitus (T1DM) on the antioxidant enzyme activities and oxidative stresses compared with healthy controls.
We studied 10 boys with T1DM (11.21 +/- 0.97 age) and 10 age-matched healthy controls (11.90 +/- 1.85 age) during the 12 weeks of moderate intensity aerobic exercise. Measurements included peak oxygen uptake, body composition, blood lipid profiles, glycated haemoglobin (HbA1c), oxidized low density lipoprotein (ox-LDL), 8-hydroxy-2'-deoxyguanosine, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities.
In T1DM patients, the baseline diastolic blood pressure and HbA1c were higher than that in controls (p < 0.05), while the GPx level was lower. The training-induced DNA damage peak was higher in T1DM patients than in controls (p < 0.05), and exercise improved both SOD and GPx levels.
Although our exercise programme increase antioxidant enzyme activities, the results of the study demonstrate that low-intensity aerobic exercise training programme performed over 12 weeks may accelerate adverse effects of antioxidant defence capacity in children with T1DM. Therefore, the future studies should be performed to clarify much more the relationship to exercise and antioxidant capacity in children with T1DM.
本研究旨在评估低强度运动训练对 1 型糖尿病（T1DM）患儿抗氧化酶活性和氧化应激的影响，并与健康对照组进行比较。
我们研究了 10 名 11.21 ± 0.97 岁的 T1DM 男孩和 10 名年龄匹配的健康对照者（11.90 ± 1.85 岁），他们在 12 周的中等强度有氧运动中接受了治疗。测量包括峰值摄氧量、身体成分、血脂谱、糖化血红蛋白（HbA1c）、氧化型低密度脂蛋白（ox-LDL）、8-羟基-2'-脱氧鸟苷、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性。
T1DM 患者的基线舒张压和 HbA1c 高于对照组（p < 0.05），而 GPx 水平较低。T1DM 患者的运动诱导 DNA 损伤峰值高于对照组（p < 0.05），运动可改善 SOD 和 GPx 水平。
尽管我们的运动方案增加了抗氧化酶的活性，但研究结果表明，12 周的低强度有氧运动训练方案可能会加速 T1DM 患儿抗氧化防御能力的不利影响。因此，未来的研究应进一步阐明 T1DM 患儿运动与抗氧化能力之间的关系。
