Department of Urology, Via Manzoni 56 - 20089 Rozzano, Milan, Italy.
BMC Cancer. 2010 Feb 23;10:62. doi: 10.1186/1471-2407-10-62.
Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.
A case is reported of a 45-years old woman with mucinous cystadenocarcinoma of the appendix with bladder metastasis. Although ultrasonography and voided urinary cytology were negative, abdomen computed tomography (CT) scan and cystoscopy and subsequent pathological examination revealed a mass exclusively located in the anterior wall of the bladder. Histopathology of the transurethral bladder resection revealed a bladder adenocarcinoma [6 cm (at the maximum diameter) x 2,5 cm; approximate weight: 10 gr] with focal mucinous aspects penetrating the muscle and perivisceral fat. Laparotomy evidenced the presence of a solid mass of the appendix (2,5 cm x 3 cm x 2 cm) extending to the loco-regional lymph nodes. Appendectomy and right hemicolectomy, linfoadenectomy and partial cystectomy were performed. The subsequent pathological examination revealed a mucinous cystadenocarcinoma of the appendix with metastatic cells colonising the anterior bladder wall and several colic lymph nodes.
The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder.
阑尾腺癌罕见，发病率为所有切除阑尾的 0.08%。有少数报道称阑尾腺癌侵犯膀胱壁是由于空间毗邻。
报道了 1 例 45 岁女性阑尾黏液性腺癌伴膀胱转移。尽管超声和尿脱落细胞学检查均为阴性，但腹部 CT 扫描、膀胱镜检查和随后的病理检查显示仅在前壁有肿块。经尿道膀胱切除术的组织病理学检查显示为膀胱腺癌[最大直径 6cm x 2.5cm；估计重量：10 克]，局部有黏液样外观，穿透肌肉和腹膜外脂肪。剖腹探查证实阑尾有一个实性肿块（2.5cm x 3cm x 2cm），延伸至局部淋巴结。行阑尾切除术和右半结肠切除术、淋巴结清扫术和部分膀胱切除术。随后的病理检查显示阑尾黏液囊腺癌，转移细胞浸润膀胱前壁和几个结肠淋巴结。
阑尾腺癌侵犯膀胱罕见，且通常累及邻近器官和膀胱后壁，我们描述了这例病例，该病例表明阑尾癌有向不同区域转移的能力。
