维生素D重要吗？维生素D在毛发疾病和毛囊周期中的作用。
Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
作者信息
Amor Karrie T, Rashid Rashid M, Mirmirani Paradi
机构信息
Department of Dermatology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Dermatol Online J. 2010 Feb 15;16(2):3.
BACKGROUND
The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology.
OBJECTIVE
We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders.
METHODS
A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss.
RESULTS
The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.
LIMITATIONS
The review is broad and there are limited human studies available to date.
CONCLUSION
Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.
背景
在皮肤病学领域，维生素D对角质形成细胞增殖和分化的作用已广为人知。
目的
我们试图评估维生素D及维生素D受体在毛发周期中的作用，并评估其在临床上如何应用于毛发疾病的治疗。
方法
进行了一项MEDLINE检索（1955年 - 2009年7月），以查找与维生素D、维生素D受体和脱发相关的文章。
结果
维生素D受体独立于维生素D，在毛发周期中发挥重要作用，特别是在生长期起始阶段。维生素D在毛囊周期中的作用尚未完全明确。
局限性
该综述范围广泛，且目前可用的人体研究有限。
结论
应开展更多研究以评估维生素D在毛发周期中的作用。上调维生素D受体的治疗方法可能成功治疗毛发疾病，是一个潜在的进一步研究领域。
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