Lin28：一个具有重要作用的 microRNA 调节因子。
Lin28: A microRNA regulator with a macro role.
机构信息
Children's Hospital Boston and Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and the Howard Hughes Medical Institute, MA 02115, USA.
出版信息
Cell. 2010 Feb 19;140(4):445-9. doi: 10.1016/j.cell.2010.02.007.
PMID:20178735
Abstract
Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.
摘要
Lin28，一种高度保守的 RNA 结合蛋白，已成为 let-7 微 RNA 加工的调节剂。Lin28 的这一作用对我们对多能性、发育时机和癌发生的机制理解具有重要意义。
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