Children's Hospital Boston and Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and the Howard Hughes Medical Institute, MA 02115, USA.
Cell. 2010 Feb 19;140(4):445-9. doi: 10.1016/j.cell.2010.02.007.
Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.
Lin28，一种高度保守的 RNA 结合蛋白，已成为 let-7 微 RNA 加工的调节剂。Lin28 的这一作用对我们对多能性、发育时机和癌发生的机制理解具有重要意义。
